21-Day Greek Isles & Adriatic: Italy & Istanbul Overnight

Day 1

4th May '28

Barcelona, Spain

On the northeast coast of Spain, overlooking the Mediterranean, Barcelona is a vibrant port city, packed with centuries of iconic art and architecture—Gaudí and Picasso both called it home—and lined with sunny white-sand beaches. Explore the Catalan capital’s tourist attractions and historic neighborhoods, Modernisme and world-renowned art museums, galleries and local crafts shops—some of which are centuries old and stock traditional Catalan wares. After you see the sights, there are lively tapas bars around every corner where you can stop for a drink, a café amb llet (Catalan for espresso with steamed milk) or a snack, no matter the hour. Green spaces for picnics, long walks and respite from the hustle and bustle are scattered throughout Barcelona’s attractions: There’s Gaudí’s mosaic-decorated park, a neoclassical maze at the Laberint d’Horta, as well as plenty of high places (mountains, monuments and edifices) where sightseeing visitors can take in the view. A short trip from Barcelona by car or train, luxury outlets, cava wineries, a mountaintop abbey and the sandy beaches of the Mediterranean coast await. More

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Arrive

0:00

Depart

17:00

Day 2

5th May '28

Villefranche-Sur-Mer

Villefranche-sur-Mer is a commune in the Alpes-Maritimes department in the Provence-Alpes-Côte d’Azur region on the French Riviera and is located south-west of the Principality of Monaco, which is just west of the French-Italian border. More

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Arrive

11:00

Depart

19:00

Day 3

6th May '28

Livorno, Italy

Access to the best of Tuscany: Florence, with its magnificent art and architecture and elegant shopping; Pisa’s Leaning Tower; and ancient Lucca. Sample shore excursions: Tuscan Countryside & Wine Tasting; Florence & the Academia. More

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Arrive

7:00

Depart

17:00

Day 4

7th May '28

Rome (tours from Civitavecchia)

When you embark on a cruise to Rome with Holland America Line you experience its bustling modernism along with its rich history. You can walk in the footsteps of emperors, have coffee in Renaissance piazzas and see contemporary art all in one afternoon. Your sightseeing time in Rome begins at the nearby port of Civitavecchia, a seaside town with roots that stretch back to the Etruscan era. Take note of the Forte Michelangelo (both Bramante and Michelangelo had a hand in its design), and the lungomare, a lively stretch along the sea with beach clubs, bars and restaurants. Once in the Eternal City you can fill your day with museums, churches, archaeological sites, traditional trattorias, artisan shops and, of course, gelato. The Colosseum and the Vatican Museums are Rome’s superstar attractions, but there are plenty of quieter gems to explore. For food lovers there are the markets in Campo de’ Fiori or the slightly farther flung Testaccio. The hip neighborhood of Monti, next to the Colosseum, has a vibrant piazza scene and boutique shopping, while the Villa Borghese offers a green oasis with a view towards Saint Peter’s Basilica and the masterpiece-filled Galleria Borghese. Although Rome might not have been built in one day, you’ll certainly be able to see its highlights on our Rome cruises along with the top things to do there in 24 hours. More

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Arrive

7:00

Depart

19:00

Day 5

8th May '28

Naples (Pompeii)

Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone – superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples’ history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions. More

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Arrive

8:00

Depart

17:00

Day 6

9th May '28

Taormina, Italy

Taormina is a hilltop town on the east coast of Sicily. It sits near Mount Etna, an active volcano with trails leading to the summit. The town is known for the Teatro Antico di Taormina, an ancient Greco-Roman theater still used today. Near the theater, cliffs drop to the sea forming coves with sandy beaches. More

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Arrive

8:00

Depart

17:00

Day 7

10th May '28

At Sea

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Arrive

0:00

Depart

0:00

Day 8

11th May '28

Souda (Chania)

The port of Souda on the Aegean Sea is home to a Greek and NATO naval base and is located six kilometers (three miles) from Chania—the second-largest city on Crete, which itself is the largest of the Greek Islands. Once you’re in Chania, set your compass for the historic waterfront with its famous Venetian Harbor dating to the 14th century. Walk along the breakwater to the restored 500-year-old lighthouse for views that are particularly photogenic from late afternoon until sunset. The atmospheric tangle of streets that is Old Town is easily explored on foot, and you can stop at one of the many outdoor cafés for a bouyatsa (custard pastry) or a glass of Cretan red wine.Soúda can also be a jumping-off point for a visit to Rethymnon, located about 54 kilometers (33 miles) to the east. Shaped by centuries of invasion, namely by the Venetians and Turks, its Fortezza was built by the Venetians in the late 16th century and captured by the Ottomans in 1646. The Old Town has the same kind of architectural character as Chania, but on a smaller scale. More

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Arrive

8:00

Depart

17:00

Day 9

12th May '28

Rhodes

Rhodes, set behind impregnable 14th-century walls, invites you to navigate through crooked streets to shop for sea sponges and visit the gorgeous Palace of the Grand Masters from where the Knights of St John set out on the Crusades. Tour to the village of Lindos and climb to the Acropolis. Look down and you’ll see where St Paul landed, as well as the rocky peninsulas where many believe the Colossus of Rhodes once stood. This 110-foot-tall statue of Helios was destroyed by an earthquake, and its remains were melted down by the Arabs for scrap metal. More

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Arrive

8:00

Depart

18:00

Day 10

13th May '28

Kusadasi (Ephesus), Turkey

Kusadasi in Turkey is the gateway to one of the most legendary cities of the ancient world: Ephesus. St. Paul preached in its Great Theater, while the facade of the Celsus Library survives as a testament to the city’s role as a center of learning and culture. Not far from Ephesus, the Temple of Artemis (also known as the Temple of Diana), one of the Seven Wonders of the ancient world, once stood, drawing pilgrims from around the Mediterranean. While it no longer stands, it is possible to walk amongst its foundations and the remains of its towering columns. Other historic sites can also be found nearby: The House of Mary is believed to be the home of Jesus’s mother at the end of her life, and the Basilica of St. John, constructed in the 6th century, marks the location of his tomb. (Like Mary, he spent his final years in Ephesus.) Nearby, the Selcuk fortress reflects the period of Byzantine and Ottoman control of the region. From ancient wonders to holy sites, there are few ports in the Mediterranean as magical as Kusadasi, and a day here is a day spent in the company of some of antiquity’s greatest figures. More

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Arrive

7:00

Depart

18:00

Day 11

14th May '28

Athens

No modern metropolis is more steeped in myth than Athens, Greece. From the gritty port of Piraeus—gateway to Greece’s fabled isles—to the Parthenon—eternal symbol of Western civilization—Athens has attracted adventurers and classicists for centuries. This heritage is still very much alive for modern visitors sightseeing in Athens: ancient stadiums and temples dwell alongside apartment blocks, modern performances are staged in the marble amphitheaters where Greek drama was born and millennia-old monuments are scattered in the archaeological park that circles the Acropolis. One of the world’s oldest maritime powers, Athens is blessed with a balmy climate and stunning coastline. The seaside suburbs of Athens are scalloped with sandy beaches, fancy yacht clubs and glamorous beach bars. While the Athenian lifestyle is known for late-night dinners and dancing until dawn, the city shines brightly by day in the bustling markets, lively cafés and fascinating museums that illuminate Greece’s past and present. Contemplate the magnitude of all that culture and ancient tourist attractions while marveling at the sun setting into the Aegean or rising over the Acropolis. More

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Arrive

7:00

Depart

15:00

Day 12

15th May '28

Kusadasi (Ephesus), Turkey

Kusadasi in Turkey is the gateway to one of the most legendary cities of the ancient world: Ephesus. St. Paul preached in its Great Theater, while the facade of the Celsus Library survives as a testament to the city’s role as a center of learning and culture. Not far from Ephesus, the Temple of Artemis (also known as the Temple of Diana), one of the Seven Wonders of the ancient world, once stood, drawing pilgrims from around the Mediterranean. While it no longer stands, it is possible to walk amongst its foundations and the remains of its towering columns. Other historic sites can also be found nearby: The House of Mary is believed to be the home of Jesus’s mother at the end of her life, and the Basilica of St. John, constructed in the 6th century, marks the location of his tomb. (Like Mary, he spent his final years in Ephesus.) Nearby, the Selcuk fortress reflects the period of Byzantine and Ottoman control of the region. From ancient wonders to holy sites, there are few ports in the Mediterranean as magical as Kusadasi, and a day here is a day spent in the company of some of antiquity’s greatest figures. More

Less

Arrive

7:00

Depart

19:00

Day 13

16th May '28

Cruising The Dardanelles

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Arrive

0:00

Depart

0:00

Day 14

17th May '28

Istanbul

Blurring the line between east and west, Istanbul stands at the crossroads of two continents. The city’s architecture is rivalled only by its spectacular natural setting on the Bosphorus Strait. See the Blue Mosque, the Topkapi Palace and the Byzantine Church of St Sophia. Take time to wander through the Grand Bazaar or the Spice Market and sample baklava and shish kebabs. More

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Arrive

7:00

Depart

0:00

Day 15

18th May '28

Istanbul

Blurring the line between east and west, Istanbul stands at the crossroads of two continents. The city’s architecture is rivalled only by its spectacular natural setting on the Bosphorus Strait. See the Blue Mosque, the Topkapi Palace and the Byzantine Church of St Sophia. Take time to wander through the Grand Bazaar or the Spice Market and sample baklava and shish kebabs. More

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Arrive

0:00

Depart

16:00

Day 16

19th May '28

Greek Isles

Informality rules on this sunny isle where pleasure-seekers from around the world come to play. Ramble along narrow streets past white-washed houses and blue-domed churches, bouganvillea-covered walls and thread-like, step-laden footpaths leading everywhere. More

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Arrive

12:00

Depart

22:00

Day 17

20th May '28

Souda (Chania)

The port of Souda on the Aegean Sea is home to a Greek and NATO naval base and is located six kilometers (three miles) from Chania—the second-largest city on Crete, which itself is the largest of the Greek Islands. Once you’re in Chania, set your compass for the historic waterfront with its famous Venetian Harbor dating to the 14th century. Walk along the breakwater to the restored 500-year-old lighthouse for views that are particularly photogenic from late afternoon until sunset. The atmospheric tangle of streets that is Old Town is easily explored on foot, and you can stop at one of the many outdoor cafés for a bouyatsa (custard pastry) or a glass of Cretan red wine.Soúda can also be a jumping-off point for a visit to Rethymnon, located about 54 kilometers (33 miles) to the east. Shaped by centuries of invasion, namely by the Venetians and Turks, its Fortezza was built by the Venetians in the late 16th century and captured by the Ottomans in 1646. The Old Town has the same kind of architectural character as Chania, but on a smaller scale. More

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Arrive

8:00

Depart

17:00

Day 18

21st May '28

Katakolon, Greece

In the quiet of the original Olympic stadium, where the torch was first lit and the winners were crowned with a laurel wreath, let your imagination run. Step into the ruined archives of Greek mythology at the Temple of Zeus—one of the few remaining Wonders of the Ancient World. More

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Arrive

10:00

Depart

18:00

Day 19

22nd May '28

Sarande

While travelers have been visiting the Albanian Riviera since antiquity, the region is, with reason, often described as up-and-coming. Long overlooked because of Albania’s political isolation from the rest of Europe, this 80-kilometer (50-mile) stretch of the northern Ionian Sea has seaside towns and stunning blue waters that visitors are now rediscovering. Strange concrete pillboxes are still visible, but other vestiges of the Communist era are thankfully fading away. The southern anchor of this coast is Sarandë, whose ancient inhabitants were said to be the descendants of the ancient Greek hero Achilles. Today, the city has become a proverbial boomtown, with the population tripling in summer. Less than 10 miles from the popular Greek tourist island of Corfu, Sarandë now sees plenty of day-trippers coming over on the short ferry ride. With a smooth horseshoe curve to its waterfront, and with fine palm-lined promenades upon which young honeymooners stroll, one wonders: What took so long? Like a mini San Francisco, the city is built around a series of stairs that lead from the top of the hill, dominated by a castle, down to the seafront. Its easy access to the sea helps explain the city’s reputation for serving excellent, fresh seafood. Sarandë is also a convenient base from which to visit a plethora of ancient ruins and UNESCO World Heritage Sites. More

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Arrive

8:00

Depart

15:00

Day 20

23rd May '28

Dubrovnik

On the southern end of Croatia’s Adriatic coast, Dubrovnik staked its claim to glory during the 450 years it existed as the independent Ragusan Republic, shoulder to shoulder with mighty forces like Venice and the Ottoman Empire. Once a renowned seafaring, shipbuilding and trading center, today it’s an enchanting tourist destination. Dubrovnik seduces sightseeing visitors with its polished (and very clean!) limestone streets, theatrical architecture, charming café, welcoming restaurants and distinctive shops along scenic side streets. The natural backdrop, much of which is protected, consists of pine and cypress forests and the shimmering Adriatic, dotted with uninhabited islands. Visitors quickly discover that the wider Dubrovnik area is just as striking as its main attraction—the Old Town. A wander around the historic heart of Dubrovnik can hit the main sights, but take it a step further (or a staircase further, really), and you’ll see that people do still live in the historic quarter, even though its polished streets make it look like a museum. You may catch the sound of a piano from the High School of Music and Arts, or hear the Dubrovnik Symphony Orchestra rehearsing in the Revelin Fortress, or encounter school kids on a break. Life unrolls as you stroll past. More

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Arrive

8:00

Depart

22:00

Day 21

24th May '28

At Sea

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0:00

Depart

0:00

Day 22

25th May '28

Trieste

Trieste is the capital city of the Friuli Venezia Giulia region in northeast Italy. A port city, it occupies a thin strip of land between the Adriatic coast and Slovenia’s border on the limestone-dominated Karst Plateau. Italian, Austro-Hungarian and Slovenian influences are all evident in its layout, which encompasses a medieval old city and a neoclassical Austrian quarter. More

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